1P-LSD (1P-LAD) – 1-Propionyl-lysergic acid diethylamide (commonly known as 1P-LSD or 1P-LAD) is a novel semi-synthetic psychedelic substance of the lysergamide chemical class that produces “classical psychedelic” effects reported to be near-identical with those of LSD when administered. Like ALD-52, it is principally theorized to act as a prodrug for LSD, not exerting any activity until it has been converted into LSD after entering the body, although there is ongoing speculation that it might possess some intrinsic activity in its own right.
The structural resemblance 1P-LSD shares with LSD suggests an extremely similar effect profile, with perhaps the only significant differences stemming from variations in the rate of absorption, duration, metabolism and excretion of the compound (i.e. its pharmacokinetic factors). Due to the lack of research relating to this substance, all following discussion relating to its pharmacology is purely based on its structural and subjective effect similarities to LSD and other designer lysergamides.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-LSD, and it has an very brief history of human usage. Over the first few months of 2015, 1P-LSD began to be marketed as a legal alternative to LSD alongside research lysergamides like ETH-LAD and AL-LAD and commercially distributed through a network of online research chemical vendors.
As with LSD itself, 1P-LSD does not meet the criteria to be considered addictive or toxic by the scientific community.Nevertheless, unpredictable adverse reactions such as anxiety, paranoia, delusions and psychotic breaks are always liable to occur, particularly among those who are predisposed to psychiatric disorders.While these negative reactions or “bad trips” can often be attributed to factors like the user’s inexperience or improper preparation of their set and setting, they are known to happen spontaneously among even the most experienced of users as well.
For this reason, it is highly advised to approach this very potent, unpredictable, long-lasting, hallucinogenic substance with the proper amount of precaution, preparation, and harm reduction practices if choosing to use it.