2-DPMP (Desoxypipradol) – Desoxypipradol (also known as 2-DPMP, 2-diphenylmethylpiperidine, or Ivory Wave) is a piperidine-based stimulant drug which is closely related to methylphenidate and pipradol.
Developed by Ciba in the 1950s and researched for applications such as the treatment of narcolepsy and ADHD; it was dropped from development after the related drug methylphenidate was developed by the same company. Methylphenidate was felt to be the superior drug for treating ADHD due to its shorter duration of action and more predictable pharmacokinetics, and while desoxypipradrol was researched for other applications (such as facilitation of rapid recovery from anesthesia), its development was not continued. However, the hydroxylated derivative pipradrol was introduced as a clinical drug indicated for depression, narcolepsy and cognitive enhancement in organic dementia.
As with methylphenidate and pipradol, it is thought to act as a norepinephrine-dopamine reuptake inhibitor (NDRI), . Of these three piperidines, it is noteworthy that desoxypipradrol has the longest elimination half-life, as it is a highly lipophilic molecule lacking polar functional groups that are typically targeted by metabolic enzymes, giving it an unusually long duration of action when compared to most stimulants. This property combined with its ultra-high potency (starting at 2mg) has given this compound a reputation for being extremely dangerous when abused or mishandled.
Desoxypipradol is a synthetic stimulant of the substituted piperidine class. It contains a substituted phenethylamine skeleton with an additional phenyl ring bound to Rα. The terminal amino group of the phenethylamine chain is incorporated into a piperidine ring. As a result of lacking polar functional groups it is a highly lipophilic molecule, giving it an extremely long-lasting multi-day duration of action that is rarely observed in stimulant drugs — notably with the exception of MDPV.
Desoxypipradol primarily acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). but one with an unusually high potency, extreme duration and unpredictable dose-response for a stimulant drug. These risks likely owe themselves to its abnormally high lipophilicity and long elimination half-life, which among other things likely increases the relative risk it has in triggering states of stimulant psychosis when abused, with which it has been demonstrated in humans to be an uncommonly low threshold.