2-Fluoromethamphetamine (2-FMA) is a synthetic ring-substituted fluorinated amphetamine compound that is commonly reported to produce classical stimulant effects such as stimulation, thought acceleration, focus and motivation enhancement when administered. It has been compared to lisdexamfetamine (Vyvanse) in its duration, potency and efficacy as a study aid or productivity enhancer.
2-FMA is one member in a series of modern designer fluorinated amphetamine analogs that includes synthetic compounds like 2-FA, 3-FA, 3-FEA and 4-FA which are known for their range of central nervous system stimulation and euphoria-producing effects, some of which have been gaining popularity as research chemical substitutes for traditional street stimulants.
A substantial increase in negative effects like high blood pressure and increased heart rate is often reported for dosages above the heavy dosage range.
2-FMA is commonly taken either orally or via insufflation as it has been reported to be highly unpleasant to vaporize compared to its parent compound. Despite its popularity as a research chemical study aid, little is known about any toxicity that may accompany its long-term use as a substitute for prescription stimulants.
2-FMA has yet to be documented being sold on the streets and is instead typically sold by online vendors as a grey market research chemical.
2-Fluoromethamphetamine (2-FMA) is a synthetic molecule of the substituted amphetamine class. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα (i.e., amphetamines are alpha-methylated phenethylamines). 2-FMA contains a methyl group bound to the terminal amine RN of the amphetamine core, a substitution it shares with methamphetamine.
2-FMA is the 2-position fluorinated analog of methamphetamine and the N-methylated homolog of 2-FA (2-fluoroamphetamine).
Although 2-FMA has not been formally studied on the same level as traditional amphetamines, it is safe to assume that just like other substituted amphetamines, it most likely acts as both a dopamine and norepinephrine releasing agent. This means it effectively increases the levels of the norepinephrine and dopamine in the brain by binding to and partially blocking the transporter proteins that normally remove them from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.