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Cocaine Powder (also known as Benzoylmethylecgonine, Coke, Snow, Blow, White, among many others) is a crystalline tropane alkaloid that is extracted from the leaves of the coca plant.It produces classical stimulant effects such as stimulation, disinhibition, thought acceleration, and euphoria when administered.
The name comes from “coca” and the alkaloid suffix “-ine”, forming “cocaine”. This substance has notably short-lived effects and is classed as a stimulant, an appetite suppressant and a local anaesthetic. It is thought to be markedly more dangerous than other CNS stimulants, including the entire amphetamine drug class.Regular use has been linked to the development of permanent heart conditions and at high doses it can cause sudden cardiac death.
Cocaine is a tropane alkaloid found in the leaves of the coca plant, Erythroxylum coca. It is most commonly consumed as the hydrochloride salt which is typically produced in clandestine laboratories. Cocaine decomposes when heated strongly so the freebase and hydrogen carbonate salts of cocaine, which have much lower boiling points compared to the hydrochloride salt, are typically used when the substance is to be vaporized and are known as cocaine base and crack respectively.
The chemical structure of cocaine consists of three parts; the hydrophilic methyl ester moiety and the lipophilic benzoyl ester moiety, which are located in place of the carboxylic acid and hydroxyl groups of ecgonine respectively. This structure allows for its rapid absorption through nasal membranes and blood-brain barrier. Cocaine can be produced synthetically but the complexity of tropane synthesis and the sophisticated equipment required compared to the relative ease of growing coca plants prevent synthesis being economically viable.
The presence of the two ester groups makes cocaine relatively unstable in warm, humid environments and cocaine stored in an open container or with a high moisture content will lose apparent potency over time due to hydrolysis to methyl ecgonine or benzoylecgonine.
Cocaine is structurally similar to atropine and scopolamine, which also contain the tropane moiety.
The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter protein’s function. This substance acts as a reuptake inhibitor and prevents dopamine from being recycled, causing excessive amounts to build up in the synapse, or junction between neurons. The result is an enhanced and prolonged post-synaptic effect of dopaminergic signaling at dopamine receptors on the receiving neuron. To a lesser extent, cocaine also exhibits functionally similar effects of reuptake inhibition upon the neurotransmitters of serotonin and noradrenaline.It is this sudden flood of neurotransmitters that causes cocaine’s characteristic high.
Even when adulterants are pharmacologically inactive, their combination with the long-term perishability of cocaine due to moisture can lead to vastly differing apparent potencies between dosages of cocaine, and as such, it can be challenging to determine a “typical” recreational dose. Pure cocaine is very potent and generates perceptible local anesthetic effects from 1 mg and perceptible CNS stimulation from 5-7 mg, however in recreational settings much higher doses tend to be preferred.
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