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5,6-Methylenedioxy-2-aminoindane (also known as MDAI Pellets) is a synthetic entactogenic substance of the aminoindane chemical class that produces effects that are associated solely with the non-stimulating serotonergic aspects of entactogens like MDMA (e.g. sedation, muscle relaxation, tactile enhancement) when administered.
MDAI was developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a putatively non-neurotoxic and highly selective serotonin releasing agent (SSRA), without the corresponding dopamine and norepinephrine release associated with typical entactogens, which reportedly limits its potential at producing overtly pro-social and euphoric effects.
MDAI has a history of being marketed alongside research chemical entactogens like 5-MAPB, 5-APB, and 6-APB as a legal, grey-market alternative to MDMA, and is almost exclusively distributed through online research chemical vendors.
MDAI, or 5,6-methylenedioxy-2-aminoindane, is a synthetic molecule of the aminoindane class with structural similarity to amphetamines. It features the R3 terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane group, a bicyclic moeity containing a benzene ring fused to a pentane ring. MDAI contains an amino group NH2 bound to R2 of the indane ring. MDAI also contains two oxygen substitutions at R5 and R6 joined by a methylene bridge to form a methylenedioxy group. MDAI is structurally related to 2-AI with the addition of a methylenedioxy ring.
MDAI has been shown to inhibit the reuptake of serotonin and has a selective affinity for the serotonin receptor. Studies show that the brains of animals treated with MDAI have greater extracellular concentrations of monoamine neural transmitters, most significantly serotonin. For comparison, MDAI is similar in potency with releasing serotonin to MDA, but significantly less potent than MDMA.This is done by inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse, essentially allowing them to accumulate, be reused and cause entactogenic effects.
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