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3,4-Methylenedioxymethamphetamine (Molly Ecstasy MDMA),commonly known as ecstasy (E), is a psychoactive drug used primarily as a recreational drug. The desired recreational effects include increased empathy, euphoria, and heightened sensations.When taken by mouth, effects begin after 30–45 minutes and last 3–6 hours.As of 2017, MDMA has no accepted medical uses.
Adverse effects of MDMA use include addiction, memory problems, paranoia, difficulty sleeping, teeth grinding, blurred vision, sweating, and a rapid heartbeat.Use may also lead to depression and fatigue.Deaths have been reported due to increased body temperature and dehydration.MDMA increases the release and slows the reuptake of the neurotransmitters serotonin, dopamine, and norepinephrine in parts of the brain. It has stimulant and psychedelic effects.The initial increase is followed by a short-term decrease in the neurotransmitters.MDMA belongs to the substituted methylenedioxyphenethylamine and substituted amphetamine classes of drugs.
MDMA was first made in 1912.It was used to improve psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s.MDMA is commonly associated with dance parties, raves, and electronic dance music.It is often sold mixed with other substances such as ephedrine, amphetamine, and methamphetamine. In 2014, between 9 and 29 million people between the ages of 15 and 64 used ecstasy (0.2% to 0.6% of the world population).This was broadly similar to the percentage of people who use cocaine, amphetamines, and opioids, but fewer than for cannabis.In the United States, about 0.9 million people used ecstasy in 2010.
MDMA is generally illegal in most countries.Limited exceptions are sometimes made for research.Researchers are investigating whether a few low doses of MDMA may assist in treating severe, treatment-resistant posttraumatic stress disorder (PTSD).In November 2016, phase 3 clinical trials for PTSD were approved by the United States Food and Drug Administration (FDA) to assess effectiveness and safety.The FDA granted MDMA a breakthrough therapy designation for the treatment of PTSD in August 2017.
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